The Reds will take a commanding lead to the Stadio Olimpico, but a late lull has given the Italians a sniff of a comeback.
The Egyptian put his former side to the sword with a stunning performance, leading the Giallorossi on a merry dance as he scored two and made two more, with Roberto Firmino (2) and Sadio Mane also getting on the scoresheet.
But the Reds allowed their visitors a sniff of a comeback ahead of their meeting in the Stadio Olimpico next Wednesday, with late goals from Edin Dzeko and Diego Perotti – the Argentine scoring from the penalty spot – keeping the door to Kiev ajar.
Roma started brightly, operating with the same 3-4-2-1 formation which had seen off Barcelona on a manic night three weeks ago, looking to slow the tempo and dictate with the ball.
The Reds were forced into an early change as Alex Oxlade-Chamberlain departed on a stretcher with a serious-looking knee injury, suffered in the act of tackling Aleksandr Kolarov; Gini Wijnaldum came on into midfield, but the England international, who has thrived playing a dual role in midfield, may well have had his season ended.
Kolarov’s next act was to fire a 30-yard thunderbolt, with little backlift, which left Loris Karius looking uncomfortable and somewhat fortunate to flick the strike onto the crossbar, when he’d seemingly been attempting to palm towards the corner flag.